JLSG-02 protocol
(2011/7 revised)
Induction A |
Ara-C |
100mg/m2/day, 6 hr drip |
days 1-5, 15-19, 29-33 |
VCR |
0.05mg/kg/day, iv |
day1, 15, 29 |
PSL |
2mg/kg/day, po |
days 1-28 |
PSL |
1mg/kg/day, po |
day 29-35 |
PSL |
0.5mg/kg/day, po |
day 36-42 |
Maintenance A |
a) AraVP |
Ara-C |
150mg/m2/day, 2 hr drip |
day 1 |
VCR |
0.05mg/kg/day, iv |
day1 |
PSL |
2mg/kg/day, po |
days 1-4 |
b) MTX/PSL |
MTX |
1mg/kg/day, iv |
day1 |
PSL |
2mg/kg/day, po |
days 1-3 |
Alternate every 2 weeks as follow: a)-b)-a)-b) ------- for 24 weeks |
Maintenance C |
a) VBL/PSL |
VBL |
6mg/m2/day, iv |
day 1 |
PSL |
2mg/kg/day, po |
days 1-4 |
b) MTX |
MTX |
20mg/m2/day, po |
day1 |
Alternate every 2 weeks as follow: a)-b)-a)-b) ------- for 24 weeks |
c) 6MP |
6MP |
1.5mg/kg/day, po |
everyday for 24 weeks |
Induction B1 |
ADR |
35mg/m2/day, iv |
day 1, 15, 29 |
CPM |
10mg/kg/day, iv |
days 1-5, 15-19, 29-33 |
VCR |
0.05mg/kg/day, iv |
day1, 15, 29 |
PSL |
2mg/kg/day, po |
days 1-5, 15-19, 29-33 |
Induction B2 |
ADR |
35mg/m2/day, iv |
day 1, 15, 29 |
CPM |
10mg/kg/day, iv |
days 1-5, 15-19, 29-33 |
VCR |
0.05mg/kg/day, iv |
day1, 15, 29 |
CSA |
3mg/kg/ day, cdiv |
day1-14 |
Maintenance B |
a) AOP |
ADR |
35mg/m2/day, iv |
day 1 |
VCR |
0.05mg/kg/day, iv |
day1 |
PSL |
2mg/kg/day, po |
days 1-5 |
b) MP |
MTX |
3mg/kg/day, 1hr drip |
day 1 |
PSL |
2mg/kg/day, po |
days 1-3 |
c) COP |
CPM |
10mg/kg/day, iv |
day 1 |
VCR |
0.05mg/kg/day, iv |
day1 |
PSL |
2mg/kg/day, po |
days 1-5 |
Alternate every 2 weeks as follow: a)-b)-c)-b)-a)-b)-c)-b) ----- for 24 weeks |
Maximum dose of VCR is 2 mg.
Maximum dose of PSL is 60mg.
Maximum dose of VBL is 6 mg.