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JAPAN ACH STUDY GROUP

JLSG-02 protocol

(2011/7 revised)

Induction A
Ara-C 100mg/m2/day, 6 hr drip days 1-5, 15-19, 29-33
VCR 0.05mg/kg/day, iv day1, 15, 29
PSL 2mg/kg/day, po days 1-28
PSL 1mg/kg/day, po day 29-35
PSL 0.5mg/kg/day, po day 36-42

Maintenance A
a) AraVP
Ara-C 150mg/m2/day, 2 hr drip day 1
VCR 0.05mg/kg/day, iv day1
PSL 2mg/kg/day, po days 1-4
b) MTX/PSL
MTX 1mg/kg/day, iv day1
PSL 2mg/kg/day, po days 1-3
Alternate every 2 weeks as follow: a)-b)-a)-b) ------- for 24 weeks

Maintenance C
a) VBL/PSL
VBL 6mg/m2/day, iv day 1
PSL 2mg/kg/day, po days 1-4
b) MTX
MTX 20mg/m2/day, po day1
Alternate every 2 weeks as follow: a)-b)-a)-b) ------- for 24 weeks
c) 6MP
6MP 1.5mg/kg/day, po everyday for 24 weeks

Induction B1
ADR 35mg/m2/day, iv day 1, 15, 29
CPM 10mg/kg/day, iv days 1-5, 15-19, 29-33
VCR 0.05mg/kg/day, iv day1, 15, 29
PSL 2mg/kg/day, po days 1-5, 15-19, 29-33

Induction B2
ADR 35mg/m2/day, iv day 1, 15, 29
CPM 10mg/kg/day, iv days 1-5, 15-19, 29-33
VCR 0.05mg/kg/day, iv day1, 15, 29
CSA 3mg/kg/ day, cdiv day1-14

Maintenance B
a) AOP
ADR 35mg/m2/day, iv day 1
VCR 0.05mg/kg/day, iv day1
PSL 2mg/kg/day, po days 1-5
b) MP
MTX 3mg/kg/day, 1hr drip day 1
PSL 2mg/kg/day, po days 1-3
c) COP
CPM 10mg/kg/day, iv day 1
VCR 0.05mg/kg/day, iv day1
PSL 2mg/kg/day, po days 1-5
Alternate every 2 weeks as follow: a)-b)-c)-b)-a)-b)-c)-b) ----- for 24 weeks

Maximum dose of VCR is 2 mg.
Maximum dose of PSL is 60mg.
Maximum dose of VBL is 6 mg.