JLSG-02 protocol
(2011/7 revised)
| Induction A |
| Ara-C |
100mg/m2/day, 6 hr drip |
days 1-5, 15-19, 29-33 |
| VCR |
0.05mg/kg/day, iv |
day1, 15, 29 |
| PSL |
2mg/kg/day, po |
days 1-28 |
| PSL |
1mg/kg/day, po |
day 29-35 |
| PSL |
0.5mg/kg/day, po |
day 36-42 |
| Maintenance A |
| a) AraVP |
| Ara-C |
150mg/m2/day, 2 hr drip |
day 1 |
| VCR |
0.05mg/kg/day, iv |
day1 |
| PSL |
2mg/kg/day, po |
days 1-4 |
| b) MTX/PSL |
| MTX |
1mg/kg/day, iv |
day1 |
| PSL |
2mg/kg/day, po |
days 1-3 |
| Alternate every 2 weeks as follow: a)-b)-a)-b) ------- for 24 weeks |
| Maintenance C |
| a) VBL/PSL |
| VBL |
6mg/m2/day, iv |
day 1 |
| PSL |
2mg/kg/day, po |
days 1-4 |
| b) MTX |
| MTX |
20mg/m2/day, po |
day1 |
| Alternate every 2 weeks as follow: a)-b)-a)-b) ------- for 24 weeks |
| c) 6MP |
| 6MP |
1.5mg/kg/day, po |
everyday for 24 weeks |
| Induction B1 |
| ADR |
35mg/m2/day, iv |
day 1, 15, 29 |
| CPM |
10mg/kg/day, iv |
days 1-5, 15-19, 29-33 |
| VCR |
0.05mg/kg/day, iv |
day1, 15, 29 |
| PSL |
2mg/kg/day, po |
days 1-5, 15-19, 29-33 |
| Induction B2 |
| ADR |
35mg/m2/day, iv |
day 1, 15, 29 |
| CPM |
10mg/kg/day, iv |
days 1-5, 15-19, 29-33 |
| VCR |
0.05mg/kg/day, iv |
day1, 15, 29 |
| CSA |
3mg/kg/ day, cdiv |
day1-14 |
| Maintenance B |
| a) AOP |
| ADR |
35mg/m2/day, iv |
day 1 |
| VCR |
0.05mg/kg/day, iv |
day1 |
| PSL |
2mg/kg/day, po |
days 1-5 |
| b) MP |
| MTX |
3mg/kg/day, 1hr drip |
day 1 |
| PSL |
2mg/kg/day, po |
days 1-3 |
| c) COP |
| CPM |
10mg/kg/day, iv |
day 1 |
| VCR |
0.05mg/kg/day, iv |
day1 |
| PSL |
2mg/kg/day, po |
days 1-5 |
| Alternate every 2 weeks as follow: a)-b)-c)-b)-a)-b)-c)-b) ----- for 24 weeks |
Maximum dose of VCR is 2 mg.
Maximum dose of PSL is 60mg.
Maximum dose of VBL is 6 mg.