JLSG-02 protocol
 (2011/7 revised)
 
                            
                            
  
    | Induction A | 
  
    | Ara-C | 100mg/m2/day, 6 hr drip | days 1-5, 15-19, 29-33 | 
  
    | VCR | 0.05mg/kg/day, iv | day1, 15, 29 | 
  
    | PSL | 2mg/kg/day, po | days 1-28 | 
  
    | PSL | 1mg/kg/day, po | day 29-35 | 
  
    | PSL | 0.5mg/kg/day, po | day 36-42 | 
  
  
    | Maintenance A | 
  
    | a) AraVP | 
  
    | Ara-C | 150mg/m2/day, 2 hr drip | day 1 | 
  
    | VCR | 0.05mg/kg/day, iv | day1 | 
  
    | PSL | 2mg/kg/day, po | days 1-4 | 
  
    | b) MTX/PSL | 
  
    | MTX | 1mg/kg/day, iv | day1 | 
  
    | PSL | 2mg/kg/day, po | days 1-3 | 
  
    | Alternate every 2 weeks as follow: a)-b)-a)-b) ------- for 24 weeks | 
    | Maintenance C | 
    | a) VBL/PSL | 
  
    | VBL | 6mg/m2/day, iv | day 1 | 
  
    | PSL | 2mg/kg/day, po | days 1-4 | 
  
    | b) MTX | 
  
    | MTX | 20mg/m2/day, po | day1 | 
  
    | Alternate every 2 weeks as follow: a)-b)-a)-b) ------- for 24 weeks | 
      
    | c) 6MP | 
      
    | 6MP | 1.5mg/kg/day, po | everyday for 24 weeks | 
    | Induction B1 | 
    | ADR | 35mg/m2/day, iv | day 1, 15, 29 | 
  
    | CPM | 10mg/kg/day, iv | days 1-5, 15-19, 29-33 | 
  
    | VCR | 0.05mg/kg/day, iv | day1, 15, 29 | 
  
    | PSL | 2mg/kg/day, po | days 1-5, 15-19, 29-33 | 
    | Induction B2 | 
    | ADR | 35mg/m2/day, iv | day 1, 15, 29 | 
  
    | CPM | 10mg/kg/day, iv | days 1-5, 15-19, 29-33 | 
  
    | VCR | 0.05mg/kg/day, iv | day1, 15, 29 | 
  
    | CSA | 3mg/kg/ day, cdiv | day1-14 | 
    | Maintenance B | 
    | a) AOP | 
  
    | ADR | 35mg/m2/day, iv | day 1 | 
  
    | VCR | 0.05mg/kg/day, iv | day1 | 
  
    | PSL | 2mg/kg/day, po | days 1-5 | 
  
    | b) MP | 
  
    | MTX | 3mg/kg/day, 1hr drip | day 1 | 
  
    | PSL | 2mg/kg/day, po | days 1-3 | 
    
    | c) COP | 
  
    | CPM | 10mg/kg/day, iv | day 1 | 
  
    | VCR | 0.05mg/kg/day, iv | day1 | 
  
    | PSL | 2mg/kg/day, po | days 1-5 | 
    
    | Alternate every 2 weeks as follow: a)-b)-c)-b)-a)-b)-c)-b) ----- for 24 weeks | 
  
Maximum dose of VCR is 2 mg.
Maximum dose of PSL is 60mg.
Maximum dose of VBL is 6 mg.